Tolerance calculator
Tolerance builds fast and fades over days. The usual advice is about two weeks for a full reset. Here is a rough picture of where you are.
Repeated dosing over a few days digs the hole deeper and takes longer to climb out of.
of a rested baseline
Partial tolerance, about 72% sensitivity.
On this rough model your usual dose would feel noticeably weaker than normal. Making up the difference with more material means more nausea and body load, and if your tolerance has faded faster than the model assumes, a much stronger experience than you planned. Waiting 6 more days is the better trade.
Effectively reset at day 9.
The mechanism
Psilocin produces its effects by binding the 5-HT2A receptor. Like many receptors under repeated agonism, 5-HT2A is thought to respond by reducing its own availability at the cell surface. Fewer available receptors means less effect from the same amount of drug, and it shows up quickly: a dose taken a day or two after another one is noticeably weaker.
Recovery takes days rather than hours. How many days has never been measured carefully in people. The common harm-reduction rule of thumb is about two weeks for a full reset, and some sources say less. The curve here is a simple exponential shaped to that rule of thumb, with a 3.5-day time constant. Read it as a rough picture, not a measurement.
Psilocybin is cross-tolerant with LSD, shown in controlled studies in the early 1960s, and LSD in turn is cross-tolerant with mescaline. Taking LSD a few days after mushrooms lands on the same reduced sensitivity.
The part worth internalising: what you reliably get from taking more material is the body load. Nausea, a racing heart, an uncomfortable plateau. And because nobody can tell you how much tolerance you actually have, extra material can also land much harder than you meant it to. The sensible reading of the tolerance curve is simply to wait.